What Is The PIK3CA Mutation? Definition & Function
Dec 18, 2025 · What Is PIK3CA? PIK3CA is a gene that gives your cells instructions for how to make a protein called p110 alpha. This protein is part of an enzyme called PI3K. PI3K helps control how your …
The Effect and Treatment of PIK3CA Mutations in Breast Cancer ...
These findings suggest that PIK3CA mutations contribute to cell proliferation, apoptosis suppression, and tumorigenesis through the activation of the PI3K/AKT/mTOR pathway. This review aimed to …
PIK3CA gene: MedlinePlus Genetics
The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). Learn about this gene and …
PIK3CA Gene - GeneCards | PK3CA Protein | PK3CA Antibody
Jan 15, 2026 · Complete information for PIK3CA gene (Protein Coding), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha, including: function, proteins, disorders, pathways, …
PIK3CA Mutation in Metastatic Cancer: Treatment and More
Mar 22, 2021 · One type of gene mutation that’s known to affect people with breast cancer is called PIK3CA. A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. It …
What Is a PIK3CA Mutation and How Does It Cause Disease?
The PIK3CA gene (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) is a fundamental component of cellular signaling pathways. Mutations within this gene are recognized as …
FDA Grants Breakthrough Designation to Zovegalisib for Breast ...
4 days ago · The FDA granted Breakthrough Therapy status to zovegalisib plus Faslodex for patients with PIK3CA-mutated HR+/HER2- advanced breast cancer.
Implications of the INAVO-120 Trial for the Treatment of
5 days ago · The INAVO-120 trial established a new standard of care for patients with <i>PIK3CA</i>-mutated, hormone receptor–positive, HER2-negative metastatic breast cancer. The combination of …
Prevalence and clinical implications of PIK3CA aberrations ...
Sep 1, 2025 · Given the challenges of therapeutic approaches targeting PIK3CA aberrations, we analyzed the incidence of PIK3CA alterations, including amplification and fusions, in 3886 patients …
Oncogenic mutations of PIK3CA lead to increased membrane ...
Jan 12, 2023 · The PIK3CA gene is one of the most frequently mutated genes in all of human cancer.