After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...

WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 19 (May 10, 2016), pp. 5447-5452 (6 pages) Protein arginine methylation, catalyzed by protein arginine ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--H3 Biomedicine Inc., a clinical stage biopharmaceutical company specializing in the discovery and development of next generation cancer therapies using its data ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 48 (November 29, 2022), pp. 1-12 (12 pages) Spliceosome activation is the process of creating the ...

A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic ...

A new imaging technique can be used to understand the workings of complex biomolecular processes at a more detailed level than previously possible. The technique marks biomolecules with organic dyes ...

The spliceosome is a macromolecular machine, containing five small nuclear RNAs and a number of proteins, that is responsible for the excision of introns from pre-mRNA species. In the September 12 ...