WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...

Bacterial fermentation products with cytostatic and antitumour activity target components of the basal precursor mRNA (pre-mRNA) splicing machinery. At least some of these drugs achieve their effects ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Watching fruit flies buzz around the ripe bananas in your kitchen, you might think it’s a tad ludicrous, mortifying even, that humans have a similar number of genes—about 23,000—as the lowly insects.

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a ...

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

This is a preview. Log in through your library . Abstract Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

In a recent paper, a team of researchers explain how the molecular machine known as the spliceosome begins the process of rearranging gene sequences in RNA splicing. Certain diseases such as cystic ...