Orphan Drug Designation applies to approximately 50,000 Patients who predominantly suffer from severe chronic pain due to ...

Potassium channels are openings that allow charged potassium atoms to cross the cell membrane. Voltage-gated potassium channels—which open only when a specific voltage is reached across the cell ...

Lysosomes are the recycling centers of human cells. Larger molecules are broken down inside the membrane-enclosed vesicles. Malfunctions can lead to neurodegenerative diseases such as Parkinson's.

Potassium channels are essential membrane proteins that enable the selective and rapid transport of K⁺ ions, a process fundamental to cellular excitability and signal transduction. Recent research has ...

This article and associated images are based on a poster originally authored by Sivakumar, M, Smith, E, Shumate, J, Scampavia, L, Spicer, T, Hernandez, D and Peters, C and presented at ELRIG Drug ...

Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

Researchers find blocking the KCNB2 gene can slow tumor growth, paving the way for next-gen treatments for childhood brain cancer. Scientists at The Hospital for Sick Children (SickKids) have ...

Following this design principle, the researchers create angstrom-scale pores in bi-layer graphene sheets, and decorate the two pore edges with twisted rings of carbonyl groups. The artificial ion ...

Researchers decipher the function of an ion channel involved in cellular degradation processes and create new possibilities for Parkinson’s therapies.