Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most ...

Species: Mouse Genes: Gba1 Modification: Gba1: Knock-In Disease Relevance: Parkinson's Disease Strain Name: Gba1 tm4Ggb Genetic Background: C57BL6, but may be mixed with 129Sv or FVB depending on the ...

The genomic and biologic conservation between mice and humans, along with our increasing ability to manipulate the mouse genome, places the mouse as a premier model for deciphering disease mechanisms ...

The goal of the Mouse Metabolic and Activity Phenotyping Core (MMPC) is to offer full mouse metabolic and activity phenotyping services to internal (CWRU) and external investigators. A basic run ...

L444P KI mice were generated using a loxP replacement vector, resulting in the insertion of a point mutation of leucine to proline (L444P) in exon 10 of the Gba1 gene (Ginns et al., 2014). These Gba1 ...

Humanized mouse models are vital for studying human gene function, but fully replacing mouse genes with complete human ...