Proline-directed phosphorylation is a posttranslational modification that is instrumental in regulating signaling from the plasma membrane to the nucleus, and its dysregulation contributes to cancer ...

PIN1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase family of proteins, which encompasses the cyclophilins, FK506-binding proteins and the parvulins. PIN1 binds to and alters ...

Like all cancers, bladder cancer develops when abnormal cells start to multiply out of control. But what if we could put a lid on their growth? Previous studies showed that a protein called PIN1 helps ...