Silent cells deep in your spinal cord may hold a surprising key to healing after devastating injuries and brain disease. A ...

Neural circuits are refined by experience with higher plasticity at younger ages. Non-neuronal brain cells, known as astrocytes, were previously seen as passive support cells, but recent research has ...

The potential effects of astrocyte dysfunction in neurodegenerative diseases are summarized in Figure 2. AD is characterized clinically by cognitive loss in two or more domains, including memory, ...

A new platform for screening astrocyte reactivity helps researchers uncover potential therapeutic interventions to treat neurodegenerative conditions. Led by postdoctoral researcher Benjamin Clayton, ...

Astrocytes in the adult brain show cellular plasticity; however, whether they have the potential to generate multiple lineages remains unclear. Here, we perform in vivo screens and identify DLX2 as a ...

Immunological memory - the ability to respond to a previously encountered antigen, or foreign substance, with greater speed and intensity on re-exposure is a hallmark of adaptive immunity. Innate ...

To do so, Papouin and his team stimulated norepinephrine secretion from mouse brain cells or exposed mouse brain slices to norepinephrine and found that norepinephrine weakened connections between ...

Delivering a connection-building protein to star-shaped cells in the brain could reverse changes to neural circuits seen in ...

We will begin by highlighting a subset of the many cellular functions of astrocytes, focusing specifically on those functions that have the most relevance to neurodegeneration (Figure 1). Other ...