In sickle cell disease, hemoglobin -- the oxygen-carrying component of blood -- forms fibers that stiffen red blood cells and cause life-threatening symptoms. Using light-scattering techniques to ...

How proteins evolved the ability to form complexes made up of multiple subunits—and what functions this new structure enabled in early multimeric proteins—isn’t well understood. To better understand ...

Chemists are reporting a new finding on how sickle cells are formed, which may lead not only to stopping their formation, but to new avenues for making uniformly-sized nanoparticles for industry.

Sickle cell disease (SCD) is a group of hereditary red blood cell disorders. Sickle cell anemia is a type of SCD that occurs when a person inherits genes containing an atypical form of hemoglobin.

Hemoglobin has played a central role in the understanding of many biochemical and biophysical principles, as Eaton and colleagues point out on page 351 of this issue of Nature Structural Biology.

Thalassemia is an inherited blood disorder that affects the production of hemoglobin and red blood cells. Symptoms include jaundice, chest pain, breathing problems, and more. Various complications can ...