Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...

TS gene promoter possesses regulatory tandemly repeated (TR) sequences that are polymorphic in humans, depending on ethnic factors. These polymorphisms have been reported to influence TS expression.

To understand how genes affect human health, researchers need to go beyond variants in the DNA sequence, and dive into the switches, or enhancers, that control when and where a gene is expressed in ...

ASHBi researchers report a new approach to reveal the temporal regulation of hundreds of gene regulatory motifs involved in neural differentiation DNA is considered the blueprint of our human bodies.

The images show the abdomen of flies in which a specific enhancer region has been modified. Depending on how much and which part of the region is modified, different areas of the pigment pattern ...

The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease. Researchers have created 3D maps of how enhancer sequences ...

About 700 million years ago, sponges branched off from all other animals on the tree of life. Despite this evolutionary distance, sponges share a form of gene regulation with much more complex species ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...