Nature

Structure of the p115RhoGEF rgRGS domain–Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator

p115RhoGEF, a guanine nucleotide exchange factor (GEF) for Rho GTPase, is also a GTPase-activating protein (GAP) for G12 and G13 heterotrimeric Gα subunits. The GAP function of p115RhoGEF resides ...
Nature

Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA

Figure 1: a Sequence alignment of the central domains of human XPA and other XPAs. The solution structure of the central domain of XPA was solved by multidimensional double and triple resonance NMR ...
News Medical

Research unveils the dual subdomain structure of the centromere

Researchers from the Kops group in collaboration with researchers from the University of Edinburgh, made a surprising new discovery in the structure of the centromere, a structure that is involved in ...
JSTOR Daily

Structure of the RECK CC domain, an evolutionary anomaly

Five small protein domains, the CC-domains, at the N terminus of the RECK protein, play essential roles in signaling by WNT7A and WNT7B in the context of central nervous system angiogenesis and ...