The Federal Government has made an unprecedented effort to publicly finance research on the effectiveness of medical treatments. The Patient Protection and Affordable Care Act of 2010 established both ...

Comparative effectiveness research and pragmatic clinical trials are valued methods to address the limitations of traditional randomized trials, answer questions of cost-effectiveness or ...

Clinical validity—the association between genotype and clinical phenotype—is now available for an increasing number of genomic applications. On the other hand, clinical utility—the improvement in ...

The objectives of this article are (1) to examine the similarities and differences between comparative effectiveness research (CER) and evidence-based medicine (EBM); (2) to describe the implications ...

Deeper concerns about CER have been raised and have always been, at their root, about how the evidence produced from CER may be applied in efforts to control health care costs. There is no doubt that ...